10.1371/journal.pcbi.1003371.g004
Eduard J. Kerkhoven
Eduard
J. Kerkhoven
Fiona Achcar
Fiona
Achcar
Vincent P. Alibu
Vincent P.
Alibu
Richard J. Burchmore
Richard
J. Burchmore
Ian H. Gilbert
Ian H.
Gilbert
Maciej Trybiło
Maciej
Trybiło
Nicole N. Driessen
Nicole
N. Driessen
David Gilbert
David
Gilbert
Rainer Breitling
Rainer
Breitling
Barbara M. Bakker
Barbara
M. Bakker
Michael P. Barrett
Michael P.
Barrett
Simulations of oxidative stress in model C.
Public Library of Science
2013
oxidative
2013-12-05 02:47:01
Figure
https://plos.figshare.com/articles/figure/Simulations_of_oxidative_stress_in_model_C_/869003
<p>(<i>A</i>) The steady state flux through the cytosolic pentose phosphate pathway in model C as a function of the oxidative stress by varying the kinetic constant <i>k<sub>TOX</sub></i>. (<i>B</i>) Fluxes through the cytosolic PPP enzymes as a function of time upon sudden oxidative stress. During the whole time-course, <i>k<sub>TOX</sub></i> = 2 µl·min<sup>−1</sup> · mg protein<sup>−1</sup>. The system is removed from steady state at <i>t</i> = 0, by setting 99% of the NAD(P)H and trypanothione pools to the oxidized form. Shown is the relaxation of the cytosolic PPP fluxes. Solid lines indicate medians, shaded areas show interquartile ranges. Near identical results were obtained for model D (<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003371#pcbi.1003371.s008" target="_blank">Figure S5</a>).</p>