Schematic overview of the models used for simulation.

(A) Detailed scheme of the modeled metabolic pathways. The numbered arrows correspond to reactions from Table 1. Extensions to the original model of glycolysis are indicated by colored shapes. Boundary metabolites are in bold, glycosomal Rib-5-P is a boundary metabolite in model C and D. (B) Schematic overview of the different models, each consisting of a unique combination of the colored modules described in (A) and Table 1. Model C and D can alternatively utilize fructose (model C^fru and D^fru), but this branch is switched off unless specifically mentioned.